Boffetta P, et al. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality – a systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol. 2017;46(3):1029–56. https://pubmed.ncbi.nlm.nih.gov/28338764/

7078

Long T, Zhang K, Chen Y, Wu C. Trends in diet quality among older US adults from 2001 to 2018. JAMA Netw Open. 2022;5(3):e221880. https://pubmed.ncbi.nlm.nih.gov/35275167/

7079

Huang Q, Braffett BH, Simmens SJ, Young HA, Ogden CL. Dietary polyphenol intake in US adults and 10-year trends: 2007–2016. J Acad Nutr Diet. 2020;120(11):1821–33. https://pubmed.ncbi.nlm.nih.gov/32807722/

7080

Long T, Zhang K, Chen Y, Wu C. Trends in diet quality among older US adults from 2001 to 2018. JAMA Netw Open. 2022;5(3):e221880. https://pubmed.ncbi.nlm.nih.gov/35275167/

7081

Rathaur P, S R JK. Metabolism and pharmacokinetics of phytochemicals in the human body. Curr Drug Metab. 2019;20(14):1085–102. https://pubmed.ncbi.nlm.nih.gov/31902349/

7082

Zhang F, Luo W, Shi Y, Fan Z, Ji G. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol. 2012;107(11):1755. https://pubmed.ncbi.nlm.nih.gov/23160295/

7083

Kong LY, Tan RX. Artemisinin, a miracle of traditional Chinese medicine. Nat Prod Rep. 2015;32(12):1617–21. https://pubmed.ncbi.nlm.nih.gov/26561737/

7084

Sharma R, Padwad Y. Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and immunosenescence during aging. Trends Food Sci Technol. 2020;98:41–52. https://www.sciencedirect.com/science/article/abs/pii/S0924224419310969

7085

Del Bo’ C, Bernardi S, Marino M, et al. Systematic review on polyphenol intake and health outcomes: is there sufficient evidence to define a health-promoting polyphenol-rich dietary pattern? Nutrients. 2019;11(6):E1355. https://pubmed.ncbi.nlm.nih.gov/31208133/

7086

Williamson G, Holst B. Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction? Br J Nutr. 2008;99 Suppl 3:S55–8. https://pubmed.ncbi.nlm.nih.gov/18598589/

7087

Ivey KL, Jensen MK, Hodgson JM, Eliassen AH, Cassidy A, Rimm EB. Association of flavonoid-rich foods and flavonoids with risk of all-cause mortality. Br J Nutr. 2017;117(10):1470–7. https://pubmed.ncbi.nlm.nih.gov/28606222/

7088

Aliper A, Belikov AV, Garazha A, et al. In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. Aging (Albany NY). 2016;8(9):2127–52. https://pubmed.ncbi.nlm.nih.gov/27677171/

7089

Lutchman V, Medkour Y, Samson E, et al. Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes. Oncotarget. 2016;7(13):16542–66. https://pubmed.ncbi.nlm.nih.gov/26918729/

7090

Navrotskaya VV, Oxenkrug G, Vorobyova LI, Summergrad P. Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster. Am J Plant Sci. 2012;3(7A):1037–40. https://pubmed.ncbi.nlm.nih.gov/26167392/

7091

Chattopadhyay D, Thirumurugan K. Longevity promoting efficacies of different plant extracts in lower model organisms. Mech Ageing Dev. 2018;171:47–57. https://pubmed.ncbi.nlm.nih.gov/29526449/

7092

Vayndorf EM, Lee SS, Liu RH. Whole apple extracts increase lifespan, healthspan and resistance to stress in Caenorhabditis elegans. J Funct Foods. 2013;5(3):1236–43. https://pubmed.ncbi.nlm.nih.gov/23878618/

7093

Chattopadhyay D, Thirumurugan K. Longevity promoting efficacies of different plant extracts in lower model organisms. Mech Ageing Dev. 2018;171:47–57. https://pubmed.ncbi.nlm.nih.gov/29526449/

7094

Dakik P, Rodriguez MEL, Junio JAB, et al. Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast. Oncotarget. 2020;11(23):2182–203. https://pubmed.ncbi.nlm.nih.gov/32577164/

7095

Chattopadhyay D, Thirumurugan K. Longevity promoting efficacies of different plant extracts in lower model organisms. Mech Ageing Dev. 2018;171:47–57. https://pubmed.ncbi.nlm.nih.gov/29526449/

7096

Shimizu C, Wakita Y, Inoue T, et al. Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). Sci Rep. 2019;9(1):3671. https://pubmed.ncbi.nlm.nih.gov/30842523/

7097

Spindler SR, Mote PL, Flegal JM, Teter B. Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice. Rejuvenation Res. 2013;16(2):143–51. https://pubmed.ncbi.nlm.nih.gov/23432089/

7098

Kitani K, Osawa T, Yokozawa T. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice. Biogerontology. 2007;8(5):567–73. https://pubmed.ncbi.nlm.nih.gov/17516143/

7099

Spindler SR, Mote PL, Flegal JM, Teter B. Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice. Rejuvenation Res. 2013;16(2):143–51. https://pubmed.ncbi.nlm.nih.gov/23432089/

7100

Harris SB, Weindruch R, Smith GS, Mickey MR, and Walford RL. Dietary restriction alone and in combination with oral ethoxyquine/2-mercaptoethylamine in mice. J Gerontol. 1990;45(5):B141–7. https://pubmed.ncbi.nlm.nih.gov/2394907/

7101

Aires DJ, Rockwell G, Wang T, et al. Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta. 2012;1822(4):522–6. https://pubmed.ncbi.nlm.nih.gov/22265987/

7102

Brykman MC, Streusand Goldman V, Sarma N, Oketch-Rabah HA, Biswas D, Giancaspro GI. What should clinicians know about dietary supplement quality? AMA J Ethics. 2022;24(5):E382–9. https://pubmed.ncbi.nlm.nih.gov/35575569/

7103

Margina D, Ilie M, Gradinaru D, Androutsopoulos VP, Kouretas D, Tsatsakis AM. Natural products – friends or foes? Toxicol Lett. 2015;236(3):154–67. https://pubmed.ncbi.nlm.nih.gov/25980574/

7104

Ames BN. Prolonging healthy aging: longevity vitamins and proteins. Proc Natl Acad Sci U S A. 2018;115(43):10836–44. https://pubmed.ncbi.nlm.nih.gov/30322941/

7105

Uysal U, Seremet S, Lamping JW, et al. Consumption of polyphenol plants may slow aging and associated diseases. Curr Pharm Des. 2013;19(34):6094–111. https://pubmed.ncbi.nlm.nih.gov/23448445/

7106

Nakatani Y, Yaguchi Y, Komura T, et al. Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans. Eur J Nutr. 2018;57(3):1137–46. https://pubmed.ncbi.nlm.nih.gov/28239780/

7107

Zuo Y, Peng C, Liang Y, et al. Sesamin extends the mean lifespan of fruit