intestinal microbiota and healthy ageing. Ageing Res Rev. 2010;9(2):107–16. https://pubmed.ncbi.nlm.nih.gov/19874918/

7399

DeJong EN, Surette MG, Bowdish DME. The gut microbiota and unhealthy aging: disentangling cause from consequence. Cell Host Microbe. 2020;28(2):180–9. https://pubmed.ncbi.nlm.nih.gov/32791111/

7400

Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488(7410):178–84. https://pubmed.ncbi.nlm.nih.gov/22797518/

7401

Biagi E, Rampelli S, Turroni S, Quercia S, Candela M, Brigidi P. The gut microbiota of centenarians: signatures of longevity in the gut microbiota profile. Mech Ageing Dev. 2017;165(Pt B):180–4. https://pubmed.ncbi.nlm.nih.gov/28049008/

7402

Rampelli S, Schnorr SL, Consolandi C, et al. Metagenome sequencing of the Hadza hunter-gatherer gut microbiota. Curr Biol. 2015;25(13):1682–93. https://pubmed.ncbi.nlm.nih.gov/25981789/

7403

Rampelli S, Soverini M, D’Amico F, et al. Shotgun metagenomics of gut microbiota in humans with up to extreme longevity and the increasing role of xenobiotic degradation. mSystems. 2020;5(2):e00124–20. https://pubmed.ncbi.nlm.nih.gov/32209716/

7404

Rampelli S, Soverini M, D’Amico F, et al. Shotgun metagenomics of gut microbiota in humans with up to extreme longevity and the increasing role of xenobiotic degradation. mSystems. 2020;5(2):e00124–20. https://pubmed.ncbi.nlm.nih.gov/32209716/

7405

Cai D, Zhao S, Li D, et al. Nutrient intake is associated with longevity characterization by metabolites and element profiles of healthy centenarians. Nutrients. 2016;8(9):E564. https://pubmed.ncbi.nlm.nih.gov/27657115/

7406

Smith P, Willemsen D, Popkes M, et al. Regulation of life span by the gut microbiota in the short-lived African turquoise killifish. eLife. 2017;6:e27014. https://pubmed.ncbi.nlm.nih.gov/28826469/

7407

Chen Y, Zhang S, Zeng B, et al. Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria. Aging (Albany NY). 2020;12(6):4778–93. https://pubmed.ncbi.nlm.nih.gov/32176868/

7408

David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–63. https://pubmed.ncbi.nlm.nih.gov/24336217/

7409

Chen Y, Zhang S, Zeng B, et al. Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria. Aging (Albany NY). 2020;12(6):4778–93. https://pubmed.ncbi.nlm.nih.gov/32176868/

7410

Kim M, Benayoun BA. The microbiome: an emerging key player in aging and longevity. Transl Med Aging. 2020;4:103–16. https://pubmed.ncbi.nlm.nih.gov/32832742/

7411

Riccio P, Rossano R. Undigested food and gut microbiota may cooperate in the pathogenesis of neuroinflammatory diseases: a matter of barriers and a proposal on the origin of organ specificity. Nutrients. 2019;11(11):E2714. https://pubmed.ncbi.nlm.nih.gov/31717475/

7412

Riccio P, Rossano R. Undigested food and gut microbiota may cooperate in the pathogenesis of neuroinflammatory diseases: a matter of barriers and a proposal on the origin of organ specificity. Nutrients. 2019;11(11):E2714. https://pubmed.ncbi.nlm.nih.gov/31717475/

7413

Patel KP, Luo FJ, Plummer NS, Hostetter TH, Meyer TW. The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores. Clin J Am Soc Nephrol. 2012;7(6):982–8. https://pubmed.ncbi.nlm.nih.gov/22490877/

7414

Riccio P, Rossano R. Undigested food and gut microbiota may cooperate in the pathogenesis of neuroinflammatory diseases: a matter of barriers and a proposal on the origin of organ specificity. Nutrients. 2019;11(11):E2714. https://pubmed.ncbi.nlm.nih.gov/31717475/

7415

Russo F, Linsalata M, Clemente C, et al. Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers. Nutr Res. 2012;32(12):940–6. https://pubmed.ncbi.nlm.nih.gov/23244539/

7416

Donnadieu-Rigole H, Pansu N, Mura T, et al. Beneficial effect of alcohol withdrawal on gut permeability and microbial translocation in patients with alcohol use disorder. Alcohol Clin Exp Res. 2018;42(1):32–40. https://pubmed.ncbi.nlm.nih.gov/29030980/

7417

Lambert GP, Schmidt A, Schwarzkopf K, Lanspa S. Effect of aspirin dose on gastrointestinal permeability. Int J Sports Med. 2012;33(6):421–5. https://pubmed.ncbi.nlm.nih.gov/22377941/

7418

Ivey KJ, Baskin WN, Krause WJ, Terry B. Effect of aspirin and acid on human jejunal mucosa. An ultrastructural study. Gastroenterology. 1979;76(1):50–6. https://pubmed.ncbi.nlm.nih.gov/758147/

7419

Tran CD, Hawkes J, Graham RD, et al. Zinc-fortified oral rehydration solution improved intestinal permeability and small intestinal mucosal recovery. Clin Pediatr (Phila). 2015;54(7):676–82. https://pubmed.ncbi.nlm.nih.gov/25520366/

7420

Ling Z, Liu X, Cheng Y, Yan X, Wu S. Gut microbiota and aging. Crit Rev Food Sci Nutr. 2022;62(13):3509–34. https://pubmed.ncbi.nlm.nih.gov/33377391/

7421

Giovannini S, Onder G, Liperoti R, et al. Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. J Am Geriatr Soc. 2011;59(9):1679–85. https://pubmed.ncbi.nlm.nih.gov/21883115/

7422

de Gonzalo-Calvo D, de Luxán-Delgado B, Martínez-Camblor P, et al. Chronic inflammation as predictor of 1-year hospitalization and mortality in elderly population. Eur J Clin Invest. 2012;42(10):1037–46. https://pubmed.ncbi.nlm.nih.gov/22624958/

7423

Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev. 2016;31:1–8. https://pubmed.ncbi.nlm.nih.gov/27592340/

7424

de Gonzalo-Calvo D, de Luxán-Delgado B, Rodríguez-González S, et al. Interleukin 6, soluble tumor necrosis factor receptor I and red blood cell distribution width as biological markers of functional dependence in an elderly population: a translational approach. Cytokine. 2012;58(2):193–8. https://pubmed.ncbi.nlm.nih.gov/22624958/

7425

Thevaranjan N, Puchta A, Schulz C, et al. Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host Microbe. 2017;21(4):455–66.e4. https://pubmed.ncbi.nlm.nih.gov/28407483/

7426

Lustgarten MS. Classifying aging as a disease: the role of microbes. Front Genet. 2016;7:212. https://pubmed.ncbi.nlm.nih.gov/27990156/

7427

Evans CJ, Ho Y, Daveson BA, et al. Place and cause of death in centenarians: a population-based observational study in England, 2001 to 2010. PLoS Med. 2014;11(6):e1001653. https://pubmed.ncbi.nlm.nih.gov/24892645/

7428

Yende S, Tuomanen EI, Wunderink R, et al. Preinfection systemic inflammatory markers and risk of hospitalization