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aetiology of post-prandial decline in testosterone in reproductive-aged men. Andrologia. 2019;51(10):e13418. https://pubmed.ncbi.nlm.nih.gov/31475727/

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Anderson KE, Rosner W, Khan MS, et al. Diet-hormone interactions: protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci. 1987;40(18):1761–8. https://pubmed.ncbi.nlm.nih.gov/3573976/

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Cook TM, Russell JM, Barker ME. Dietary advice for muscularity, leanness and weight control in Men’s Health magazine: a content analysis. BMC Public Health. 2014;14:1062. https://pubmed.ncbi.nlm.nih.gov/25304148/

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Schwartz A, Hunschede S, Lacombe RJS, et al. Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males. Clin Endocrinol (Oxf). 2019;91(2):295–303. https://pubmed.ncbi.nlm.nih.gov/31055857/

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Whittaker J, Harris M. Low-carbohydrate diets and men’s cortisol and testosterone: systematic review and meta-analysis. Nutr Health. 2022;28(4):543–54. https://pubmed.ncbi.nlm.nih.gov/35254136/

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Schwartz A, Hunschede S, Lacombe RJS, et al. Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males. Clin Endocrinol (Oxf). 2019;91(2):295–303. https://pubmed.ncbi.nlm.nih.gov/31055857/

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Messina M. Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence. Fertil Steril. 2010;93(7):2095–104. https://pubmed.ncbi.nlm.nih.gov/20378106/

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Hamilton-Reeves JM, Vazquez G, Duval SJ, Phipps WR, Kurzer MS, Messina MJ. Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Fertil Steril. 2010;94(3):997–1007. https://pubmed.ncbi.nlm.nih.gov/19524224/

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Shultz TD, Bonorden WR, Seaman WR. Effect of short-term flaxseed consumption on lignan and sex hormone metabolism in men. Nutr Res. 1991;11(10):1089–100. https://www.sciencedirect.com/science/article/abs/pii/S0271531705806876

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Takenaka T, Nagano M, Yamashita K, Kikuchi K. Flaxseed oil stimulates gynecomastia. BMJ Case Rep. 2020;13(12):e237948. https://pubmed.ncbi.nlm.nih.gov/33303502/

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Schwartz LM, Woloshin S. Low “T” as in “template”: how to sell disease. JAMA Intern Med. 2013;173(15):1460–2. https://pubmed.ncbi.nlm.nih.gov/23939516/

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Shores MM, Matsumoto AM. Testosterone, aging and survival: biomarker or deficiency. Curr Opin Endocrinol Diabetes Obes. 2014;21(3):209–16. https://pubmed.ncbi.nlm.nih.gov/24722173/

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Fugh-Berman A. Treating aging with testosterone. Am Fam Physician. 2017;96(7):428–30. https://pubmed.ncbi.nlm.nih.gov/29094915/

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Lee JH, Shah PH, Uma D, Salvi DJ, Rabbani R, Hamid P. Testosterone replacement therapy in hypogonadal men and myocardial infarction risk: systematic review & meta-analysis. Cureus. 2021;13(8):e17475. https://pubmed.ncbi.nlm.nih.gov/34513525/

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Vigen R, O’Donnell CI, Barón AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310(17):1829–36. https://pubmed.ncbi.nlm.nih.gov/24193080/

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Regan JC, Partridge L. Gender and longevity: why men die earlier than women? Comparative and experimental evidence. Best Pract Res Clin Endocrinol Metab. 2013;27(4):467–79. https://pubmed.ncbi.nlm.nih.gov/24054925/

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Tremellen K. Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) – a novel theory for the development of late onset hypogonadism in obese men. Basic Clin Androl. 2016;26:7. https://pubmed.ncbi.nlm.nih.gov/27340554/

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Lang PO, Samaras D, Samaras N. Testosterone replacement therapy in reversing “andropause”: what is the proof-of-principle? Rejuvenation Res. 2012;15(5):453–65. https://pubmed.ncbi.nlm.nih.gov/22656862/

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Regan JC, Partridge L. Gender and longevity: why men die earlier than women? Comparative and experimental evidence. Best Pract Res Clin Endocrinol Metab. 2013;27(4):467–79. https://pubmed.ncbi.nlm.nih.gov/24054925/

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Tremellen K. Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) – a novel theory for the development of late onset hypogonadism in obese men. Basic Clin Androl. 2016;26:7. https://pubmed.ncbi.nlm.nih.gov/27340554/

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Garratt M, Stout MB. Hormone actions controlling sex-specific life-extension. Aging (Albany NY). 2018;10(3):293–4. https://pubmed.ncbi.nlm.nih.gov/29514132/

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Drori D, Folman Y. Interactive environmental and genetic effects on longevity in the male rat: litter size, exercise, electric shocks and castration. Exp Aging Res. 1986;12(2):59–64. https://pubmed.ncbi.nlm.nih.gov/3569385/

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Min KJ, Lee CK, Park HN. The lifespan of Korean eunuchs. Curr Biol. 2012;22(18):R792–3. https://pubmed.ncbi.nlm.nih.gov/23017989/

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Le Bourg É. No ground for advocating that Korean eunuchs lived longer than intact men. Gerontology. 2015;62(1):69–70. https://pubmed.ncbi.nlm.nih.gov/26138349/

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Nieschlag E, Nieschlag S, Behre HM. Lifespan and testosterone. Nature. 1993;366(6452):215. https://pubmed.ncbi.nlm.nih.gov/8232579/

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Spiegel AM. The Jeremiah Metzger lecture: a brief history of eugenics in America: implications for medicine in the 21st century. Trans Am Clin Climatol Assoc. 2019;130:216–34. https://pubmed.ncbi.nlm.nih.gov/31516187/

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Hamilton JB, Mestler GE. Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population. J Gerontol. 1969;24(4):395–411. https://pubmed.ncbi.nlm.nih.gov/5362349/

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Handelsman DJ. Testosterone and male aging: faltering hope for rejuvenation. JAMA. 2017;317(7):699–701. https://pubmed.ncbi.nlm.nih.gov/28241336/

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Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013;123(3):958–65. https://pubmed.ncbi.nlm.nih.gov/23454758/

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Alam I, Almajwal AM, Alam W, et al. The immune-nutrition interplay in aging – facts and controversies. Nutr Healthy Aging. 2019;5(2):73–95. https://content.iospress.com/articles/nutrition-and-healthy-aging/nha170034

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Xu W, Wong G, Hwang YY, Larbi A. The untwining of immunosenescence and aging. Semin Immunopathol. 2020;42(5):559–72. https://pubmed.ncbi.nlm.nih.gov/33165716/

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Crooke SN, Ovsyannikova IG, Poland GA, Kennedy RB. Immunosenescence and human vaccine immune responses. Immun Ageing. 2019;16:25. https://pubmed.ncbi.nlm.nih.gov/31528180/

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Fagiolo U, Cossarizza A, Scala E, et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 1993;23(9):2375–8. https://pubmed.ncbi.nlm.nih.gov/8370415/

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Cevenini E, Monti D, Franceschi C. Inflamm-ageing. Curr Opin Clin Nutr Metab Care. 2013;16(1):14–20. https://pubmed.ncbi.nlm.nih.gov/23132168/

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Crimmins EM. Age-related vulnerability to

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