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review and in-depth analysis of the evidence. Pharmacol Res Perspect. 2020;8(5):e00651. https://pubmed.ncbi.nlm.nih.gov/32996701/

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Safer DJ. Overprescribed medications for US adults: four major examples. J Clin Med Res. 2019;11(9):617–22. https://pubmed.ncbi.nlm.nih.gov/31523334/

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Newberry C, Lynch K. The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn. J Thorac Dis. 2019;11(Suppl 12):S1594–601. https://pubmed.ncbi.nlm.nih.gov/31489226/

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Jung JG, Kang HW. Vegetarianism and the risk of gastroesophageal reflux disease. In: Vegetarian and Plant-Based Diets in Health and Disease Prevention. Elsevier; 2017:463–72. https://www.sciencedirect.com/science/article/abs/pii/B9780128039687000253?via%3Dihub

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Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997;315(7112):841–6. https://pubmed.ncbi.nlm.nih.gov/9353503/

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Patel RA, Wilson RF, Patel PA, Palmer RM. The effect of smoking on bone healing. Bone Joint Res. 2013;2(6):102–11. https://pubmed.ncbi.nlm.nih.gov/23836474/

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Kim JH, Patel S. Is it worth discriminating against patients who smoke? A systematic literature review on the effects of tobacco use in foot and ankle surgery. J Foot Ankle Surg. 2017;56(3):594–9. https://pubmed.ncbi.nlm.nih.gov/28476393/

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Bourne D, Plinke W, Hooker ER, Nielson CM. Cannabis use and bone mineral density: NHANES 2007–2010. Arch Osteoporos. 2017;12(1):29. https://pubmed.ncbi.nlm.nih.gov/28286929/

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Sophocleous A, Robertson R, Ferreira NB, McKenzie J, Fraser WD, Ralston SH. Heavy cannabis use is associated with low bone mineral density and an increased risk of fractures. Am J Med. 2017;130(2):214–21. https://pubmed.ncbi.nlm.nih.gov/27593602/

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Wright J. Marketing disease: is osteoporosis an example of “disease mongering”? Br J Nurs. 2009;18(17):1064–7. https://pubmed.ncbi.nlm.nih.gov/19798007/

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Black DM, Rosen CJ. Postmenopausal osteoporosis. N Engl J Med. 2016;374(21):2096–7. https://pubmed.ncbi.nlm.nih.gov/26789873/

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Lems WF, Raterman HG. Critical issues and current challenges in osteoporosis and fracture prevention. An overview of unmet needs. Ther Adv Musculoskelet Dis. 2017;9(12):299–316. https://pubmed.ncbi.nlm.nih.gov/29201155/

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Kolata G. Fearing drugs’ rare side effects, millions take their chances with osteoporosis. The New York Times. https://www.nytimes.com/2016/06/02/health/osteoporosis-drugs-bones.html. Published June 1, 2016. Accessed March 6, 2022.; https://www.nytimes.com/2016/06/02/health/osteoporosis-drugs-bones.html

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Sales LP, Pinto AJ, Rodrigues SF, et al. Creatine supplementation (3 g/d) and bone health in older women: a 2-year, randomized, placebo-controlled trial. J Gerontol A Biol Sci Med Sci. 2020;75(5):931–8. https://pubmed.ncbi.nlm.nih.gov/31257405/

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Candow DG, Forbes SC, Kirk B, Duque G. Current evidence and possible future applications of creatine supplementation for older adults. Nutrients. 2021;13(3):745. https://pubmed.ncbi.nlm.nih.gov/33652673/

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NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285(6):785–95. https://pubmed.ncbi.nlm.nih.gov/11440324/

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Nestle M, Nesheim MC. To supplement or not to supplement: the U.S. Preventive Services Task Force recommendations on calcium and vitamin D. Ann Intern Med. 2013;158(9):701–2. https://pubmed.ncbi.nlm.nih.gov/23440174/

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Grossman DC, Curry SJ, Owens DK, et al. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults: US Preventive Services Task Force recommendation statement. JAMA. 2018;319(15):1592–9. https://pubmed.ncbi.nlm.nih.gov/29677309/

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Bolland MJ, Grey A, Reid IR. Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf. 2013;4(5):199–210. https://pubmed.ncbi.nlm.nih.gov/25114781/

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Reid IR, Bristow SM, Bolland MJ. Calcium supplements: benefits and risks. J Intern Med. 2015;278(4):354–68. https://pubmed.ncbi.nlm.nih.gov/26174589/

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Reid IR, Bolland MJ. Risk factors: calcium supplements and cardiovascular risk. Nat Rev Cardiol. 2012;9(9):497–8. https://pubmed.ncbi.nlm.nih.gov/22776986/

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Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr. 2007;86(6):1780–90. https://pubmed.ncbi.nlm.nih.gov/18065599/

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Bolland MJ, Grey A, Reid IR. Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf. 2013;4(5):199–210. https://pubmed.ncbi.nlm.nih.gov/25114781/

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Willett WC, Ludwig DS. Milk and health. N Engl J Med. 2020;382(7):644–54. https://pubmed.ncbi.nlm.nih.gov/32053300/

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Dawson-Hughes B, Jacques P, Shipp C. Dietary calcium intake and bone loss from the spine in healthy postmenopausal women. Am J Clin Nutr. 1987;46(4):685–7. https://pubmed.ncbi.nlm.nih.gov/3661483/

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Sanders KM, Stuart AL, Williamson EJ, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815–22. https://pubmed.ncbi.nlm.nih.gov/20460620/

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Ginde AA, Blatchford P, Breese K, et al. High-dose monthly vitamin D for prevention of acute respiratory infection in older long-term care residents:

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